4,9-DIMETHOXY-7-METHYL-5H-FURO[3,2-G]-[1]BENZOPYRAN-5-ONE
khellin
CAS: 82-02-0
Molecular Formula: C14H12O5
4,9-DIMETHOXY-7-METHYL-5H-FURO[3,2-G]-[1]BENZOPYRAN-5-ONE - Names and Identifiers
| Name | khellin |
| Synonyms | norkel ammivin khellin ammispasmin ammivisnagen 4,9-dimethoxy-7-methylfurano(3,2-g)chromen-5-one 4,9-dimethoxy-7-methyl-5H-furo[3,2-g]chromen-5-one 4,9-dimethoxy-7-methyl-5-oxo-1,8-dioxabenz-(f)indene 4,9-DIMETHOXY-7-METHYLFURO[3,2-G](1)BENZOPYRAN-5-ONE 2-g)(1)benzopyran-5-one,4,9-dimethoxy-7-methyl-5h-furo( 4,9-DIMETHOXY-7-METHYL-5H-FURO[3,2-G]-[1]BENZOPYRAN-5-ONE |
| CAS | 82-02-0 |
| EINECS | 201-392-8 |
| InChI | InChI=1/C14H12O5/c1-7-6-9(15)10-11(16-2)8-4-5-18-12(8)14(17-3)13(10)19-7/h4-6H,1-3H3 |
4,9-DIMETHOXY-7-METHYL-5H-FURO[3,2-G]-[1]BENZOPYRAN-5-ONE - Physico-chemical Properties
| Molecular Formula | C14H12O5 |
| Molar Mass | 260.24 |
| Density | 1.1954 (rough estimate) |
| Melting Point | 150154°C |
| Boling Point | 180200°C0.05mm Hg |
| Flash Point | 218.8°C |
| Water Solubility | 247.2g/L(25 ºC) |
| Solubility | Chloroform (Slightly), Methanol (Slightly) |
| Vapor Presure | 1.88E-09mmHg at 25°C |
| Appearance | Bright yellow powder |
| Color | light yellow |
| Merck | 14,5309 |
| BRN | 263185 |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.4560 (estimate) |
| MDL | MFCD00005007 |
| In vitro study | Khelline exhibits anti-proliferative activity for MCF-7 cells and Hela cells. Khellin inhibits the pathways of Ca 2+ influx which are activated by both noradrenaline and high K + . |
4,9-DIMETHOXY-7-METHYL-5H-FURO[3,2-G]-[1]BENZOPYRAN-5-ONE - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | R25 - Toxic if swallowed R38 - Irritating to the skin R36/37/38 - Irritating to eyes, respiratory system and skin. R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. |
| Safety Description | S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| UN IDs | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | LV1050000 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
| Toxicity | LD50 in mice, rats (mg/kg): 30.6, 34.4 i.v.; 50.8, 68.8 orally (Busch) |
4,9-DIMETHOXY-7-METHYL-5H-FURO[3,2-G]-[1]BENZOPYRAN-5-ONE - Reference Information
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| biological activity | Khellin (Methafrone, Visammin, Ammivisnagen, Khellinorm, Medekellin, Viscardan, Anglin) isolated from the seeds of amitriasis (Umbelliferae), it is used to treat a variety of diseases. |
| Target | IC50: 0.15 µm (EGFR) |
| category | toxic substances |
| toxicity grade | high toxicity |
| Acute toxicity | oral-rat LD50: 68.8 mg kg; Oral-mouse LD50: 50.8 mg/kg |
| flammability hazard characteristics | flammable; Combustion-induced irritating smoke |
| storage and transportation characteristics | warehouse ventilation and low temperature drying |
| extinguishing agent | dry powder, foam, sand, carbon dioxide, water mist |
Last Update：2024-04-10 22:29:15
![4,9-DIMETHOXY-7-METHYL-5H-FURO[3,2-G]-[1]BENZOPYRAN-5-ONE](http://res.chembk.com/assets/str/2d/8/82/82-02-0.png)
Supplier List
Featured ProductsSpot supply
Product Name: Khellin Visit Supplier Webpage Request for quotationCAS: 82-02-0
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Multiple SpecificationsSpot supply
Product Name: Khellin Visit Supplier Webpage Request for quotationCAS: 82-02-0
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: khellin Visit Supplier Webpage Request for quotationCAS: 82-02-0
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Multiple SpecificationsSpot supply
Product Name: Khellin Visit Supplier Webpage Request for quotationCAS: 82-02-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Featured ProductsSpot supply
Product Name: Khellin Visit Supplier Webpage Request for quotationCAS: 82-02-0
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Multiple SpecificationsSpot supply
Product Name: Khellin Visit Supplier Webpage Request for quotationCAS: 82-02-0
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: khellin Visit Supplier Webpage Request for quotationCAS: 82-02-0
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Multiple SpecificationsSpot supply
Product Name: Khellin Visit Supplier Webpage Request for quotationCAS: 82-02-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
4,9-DIMETHOXY-7-METHYL-5H-FURO[3,2-G]-[1]BENZOPYRAN-5-ONE
methyl 1-methyl-2-thioxo-1,2-dihydro-4-pyridinecarboxylate
2-(naphthalen-2-ylmethyl)oxirane
5-Nitro-2-Furoyl Chloride
2-[[4-Chloro-6-[[8-hydroxy-7-[(2-sulfophenyl) azo]-3,6-disulfo-1-naphthalenyl]amino]-1,3,5-triazin-2-yl]amino]-5-sulfobenzoic acid, tetraosodium salt
2-{2-[4-(allyloxy)-3-ethoxybenzylidene]hydrazino}-N-(4-chloro-2-methylphenyl)-2-oxoacetamide
1163303-54-5
354786-78-0
N-phenyl-2-(pyrimidin-2-ylthio)acetamide
6-(2-Cyanoethyl)imidazo[1,2-a]pyridine-3-carboxylic acid
methyl 1-methyl-2-thioxo-1,2-dihydro-4-pyridinecarboxylate
2-(naphthalen-2-ylmethyl)oxirane
5-Nitro-2-Furoyl Chloride
2-[[4-Chloro-6-[[8-hydroxy-7-[(2-sulfophenyl) azo]-3,6-disulfo-1-naphthalenyl]amino]-1,3,5-triazin-2-yl]amino]-5-sulfobenzoic acid, tetraosodium salt
2-{2-[4-(allyloxy)-3-ethoxybenzylidene]hydrazino}-N-(4-chloro-2-methylphenyl)-2-oxoacetamide
1163303-54-5
354786-78-0
N-phenyl-2-(pyrimidin-2-ylthio)acetamide
6-(2-Cyanoethyl)imidazo[1,2-a]pyridine-3-carboxylic acid